Dr. Catherine A. Sarisky

Associate Professor of Chemistry, Associate Director of the Honors Program

Education

  • New College of the University of South Florida
    BA in Chemistry, 1995
  • California Institute of Technology
    Ph. D. in Chemistry, 2005

Current & Recent Courses

  • Chem 111-112 - General Chemistry
  • Chem 221-222 - Organic Chemistry I-II
  • Chem 280 - Communicating Chemistry (Sophomore seminar)
  • Chem 340 - Pharmaceutical Chemistry
  • HNRS 105 - The Freshman Experience (focusing on the pharmaceutical industry and the FDA)
  • HNRS 301 - Medical Evidence

Research Interests

  • Biosynthesis of purines in Archaea. My student collaborators and I are studying how microorganisms called Archaea convert available resources into purines, which are required for DNA and RNA synthesis. A description of my work with students can be found here.

Publications

Brown AM, Hoopes SL, White RH, Sarisky CA (2011)  Purine Biosynthesis: Variations on a Theme.  Biology Direct.  6:63.  (Free full text)
Hancock AN, Coleman RS, Johnson RT, Sarisky CA, and Johann TW. (2008). Investigations of the roles of Arginine 115 and Lysine 120 in the Active site of 5,10-methenyltetrahydrofolate synthetase from Mycoplasma pneumoniae. Protein J. 27, 303-308. (Abstract)
Offredi F., Dubail F., Kischel P., Sarisky C. A., Stern A. S., Van de Weerdt C., Hoch J. C., Prosperi C., Francois J. M., Mayo S. L., Martial J. A. (2002). De novo Backbone and Sequence Design of an Idealized beta-barrel Protein: Evidence of Stable Tertiary Structure. J. Mol. Biol. 325, 163-174.
Sarisky C. A. and Mayo S. L. (2001). The ββα fold: Explorations in sequence space. J. Mol. Biol. 307(5), 1411-8.
Ross S., Sarisky C. A., Su A., Mayo S. L. (2000). Designed protein G core variants fold to native-like structures: sequence selection by ORBIT tolerates variation in backbone specification. Protein Sci. 10(2), 450-4.
Hammack B., Attfield K., Clayton D., Dec E., Dong A., Sarisky C., Bowler B. E. (1998). The magnitude of changes in guanidine-HCl unfolding m-values in the protein, iso-1-cytochrome c, depends upon the substructure containing the mutation. Protein Sci. 7, 1789-1795.
Dahiyat B. I., Sarisky C. A., and Mayo S. L. (1997). De novo protein design: Towards fully automated sequence selection. J. Mol. Biol. 273(4), 789-796.

Recent Presentations and Invited talks

  • "A Tale of Two Archaeal IMP Cyclohydrolases"  Gordon Research Conference: Archaea, Waterville Valley, NH, July 2011.
  • "De novo purine biosynthesis in archaea: still more to learn." Gordon Research Conference: Archaea, Waterville Valley, NH, July 2009.
  • "Purine biosynthesis in Archaea: Variations on a Theme." ACS National meeting, New Orleans, April 2008.
  • "Online homework: Lessons Learned." ACS National Meeting, New Orleans, April 2008.
  • "When Chemists do Biology: Tales from the Interface." Virginia Tech Visiting Scholar Seminar Series. November 17, 2005.

Recent Awards & Honors

  • Single Investigator Cottrell College Science Award, 2010
  • Research Grant from the Jeffress Memorial Trust, 2007. Renewed 2009, 2011.
  • Faculty Starter Grant, Roanoke College, 2007
  • Research Grant from The Thomas F. and Kate Miller Jeffress Memorial Trust (with T. Johann), 2005



Contact Information

Street address
Chemistry Department,
Roanoke College
221 College Lane
Salem, VA 24153-3794

E-mail
sarisky@roanoke.edu

Office
Trexler 565A
540 375-2438

Fax
540 375-2055

 
Forensic Chemistry Course Modeled After Crime Lab

Forensic Chemistry Course Modeled After Crime Lab

Crime investigation shows likes CSI, Law and Order, and Without a Trace will be a classroom and laboratory experience taught by Dr. Benjamin Huddle

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Upcoming EPIC Events

04/04/14, 3:30 pm, Dr. Weiss

04/11/14, 4:00 pm, Ms. Soublo

04/11/14, Poster Session

04/17/14, Dr. Anderson

See EPiC Calendar for more events.