Charles Edward Webber was born on January 17, 1900 in Salem Virginia. He was educated in the local public schools before attending Roanoke College. He graduated from Roanoke in 1922 before earning his Registered Pharmacy that same year from the State Board of Pharmacy. At Roanoke he was a member of the XI Chapter of the Pi Kappa Phi Fraternity. He was awarded the Outstanding Alumni Pi Kappa Phi Fraternity award for the XI Chapter in 1964. Webber also received the Golden Legion Award in 1969 for the Pi Kappa Phi Fraternity.
Webber enlisted in the United States Army in October in 1918, and was a member of Selective Service System during World War II. He was presented the Selective Service Medal, awarded in the name of the Congress of the United States for faithful and loyal service. He was also a charter member of the American Legion Salem Post number 19 for 52 years.
Webber owned and operated Webber's Pharmacy from 1925-1959. He was elected to the Board of Directors of the Farmers National Bank of Salem in 1932, vice president in 1941, and named President of the Nation Bank in 1954. He served as president until 1653, and then became the chairman of the board of directors. Webber followed that position when he was elected Acting president, a post that he served until 1970. In April 1971, he received a special citation for "outstanding service" to Farmers National Bank. He retired as a Pharmacist Banker.
Webber was a member of the First United Methodist Church in Salem for 64 years, and was Treasurer of the church from 1934-1959. He was also a member of the Board of Stewards for over 30 years, and was also a member of the Board of Trustees for that same organization. Other memberships that Webber was a part of included the Navy League of the United States and the 1900 Club. He was appointed Director of the Virginia Brick Company and the Virginia Western Community College Board in 1970.
Charles E. Webber married Pauline Graham Webber on November 2, 1922. They had two children together; Charles E. Webber, Jr. and Jean Webber Payne.